ID   ED-40515
AC   CVCL_JF68
SY   ED-40515(+); ED40515
DR   GEO; GSE168552
DR   RCB; RCB3533
DR   Wikidata; Q54831949
RX   PubMed=2866223;
RX   PubMed=7662981;
RX   PubMed=15638850;
RX   PubMed=16314839;
RX   PubMed=32210945;
RX   PubMed=34794206;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_JF69 ! ED-40810
OI   CVCL_A6SI ! ED-41214
OI   CVCL_A6SJ ! ED-70423C
OI   CVCL_A6SK ! ED-50823
SX   Male
AG   34Y
CA   Cancer cell line
DT   Created: 15-05-17; Last updated: 29-06-23; Version: 10
//
RX   PubMed=2866223; DOI=10.1084/jem.162.6.2169;
RA   Maeda M., Shimizu A., Ikuta K., Okamoto H., Kashihara M., Uchiyama T.,
RA   Honjo T., Yodoi J.;
RT   "Origin of human T-lymphotrophic virus I-positive T cell lines in
RT   adult T cell leukemia. Analysis of T cell receptor gene
RT   rearrangement.";
RL   J. Exp. Med. 162:2169-2174(1985).
//
RX   PubMed=7662981; DOI=10.1182/blood.V86.6.2350.bloodjournal8662350;
RA   Imada K., Takaori-Kondo A., Akagi T., Shimotohno K., Sugamura K.,
RA   Hattori T., Yamabe H., Okuma M., Uchiyama T.;
RT   "Tumorigenicity of human T-cell leukemia virus type I-infected cell
RT   lines in severe combined immunodeficient mice and characterization of
RT   the cells proliferating in vivo.";
RL   Blood 86:2350-2357(1995).
//
RX   PubMed=15638850; DOI=10.1111/j.1365-2141.2004.05255.x;
RA   Ueda M., Imada K., Imura A., Koga H., Hishizawa M., Uchiyama T.;
RT   "Expression of functional interleukin-21 receptor on adult T-cell
RT   leukaemia cells.";
RL   Br. J. Haematol. 128:169-176(2005).
//
RX   PubMed=16314839; DOI=10.1038/sj.onc.1209256;
RA   Ahsan M.K., Masutani H., Yamaguchi Y., Kim Y.-C., Nosaka K.,
RA   Matsuoka M., Nishinaka Y., Maeda M., Yodoi J.;
RT   "Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene
RT   silencing of thioredoxin-binding protein-2.";
RL   Oncogene 25:2181-2191(2006).
//
RX   PubMed=32210945; DOI=10.3389/fmicb.2020.00356;
RA   Maeda M., Tanabe-Shibuya J., Miyazato P., Masutani H., Yasunaga J.-i.,
RA   Usami K., Shimizu A., Matsuoka M.;
RT   "IL-2/IL-2 receptor pathway plays a crucial role in the growth and
RT   malignant transformation of HTLV-1-infected T cells to develop adult
RT   T-cell leukemia.";
RL   Front. Microbiol. 11:356.1-356.17(2020).
//
RX   PubMed=34794206; DOI=10.1111/cas.15204;
RA   Ikebe E., Shimosaki S., Hasegawa H., Iha H., Tsukamoto Y., Wang Y.,
RA   Sasaki D., Imaizumi Y., Miyazaki Y., Yanagihara K., Hamaguchi I.,
RA   Morishita K.;
RT   "TAS-116 (pimitespib), a heat shock protein 90 inhibitor, shows
RT   efficacy in preclinical models of adult T-cell leukemia.";
RL   Cancer Sci. 113:684-696(2022).
//