ID   NtG20.i7
AC   CVCL_JA65
DR   cancercelllines; CVCL_JA65
DR   Wikidata; Q54931114
RX   PubMed=28338936;
CC   Population: Caucasian.
CC   Virology: Supports hepatitis B virus (HBV) replication for up to 35 days with production of infectious HBV in the culture supernatant.
CC   Knockout cell: Method=shRNA knockdown; HGNC; HGNC:29233; MAVS.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:10905; SLC10A1.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 15-05-17; Last updated: 10-04-25; Version: 18
//
RX   PubMed=28338936; DOI=10.1093/intimm/dxx012;
RA   Yao W.-L., Ikeda S., Tsukamoto Y., Shindo K., Otakaki Y., Qin M.,
RA   Iwasawa Y., Takeuchi F., Kaname Y., Chou Y.-C., Chang C.-M., Watashi K.,
RA   Wakita T., Noda T., Kato H., Fujita T.;
RT   "Establishment of a human hepatocellular cell line capable of
RT   maintaining long-term replication of hepatitis B virus.";
RL   Int. Immunol. 29:109-120(2017).
//