ID   HB4a
AC   CVCL_J982
SY   Hb-4a; HB 4a
DR   BTO; BTO_0003893
DR   ChEMBL-Cells; CHEMBL3308647
DR   ChEMBL-Targets; CHEMBL614786
DR   Cosmic; 687470
DR   Cosmic; 1609467
DR   PRIDE; PXD004195
DR   PubChem_Cell_line; CVCL_J982
DR   Wikidata; Q54881361
RX   CelloPub=CLPUB00734;
RX   PubMed=8206680;
RX   PubMed=11044355;
RX   PubMed=12671075;
RX   PubMed=16685446;
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/hb4a.htm
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58+U19).
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; Massively parallel signature sequencing (MPSS).
CC   Donor information: Established from reduction mammoplasty tissue (PubMed=8206680).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_E3WV ! HB4b
OI   CVCL_E3WW ! HB4c
SX   Female
AG   18Y
CA   Conditionally immortalized cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 19
//
RX   CelloPub=CLPUB00734;
RA   Silva A.P.M., Carraro D.M., Pires L.C., Jongeneel C.V., De Souza S.J.,
RA   Camargo A.A.;
RT   "Characterization of novel c-erbB2 regulated genes using massively
RT   parallel signature sequencing (MPSS).";
RL   Cancer Res. 66 Suppl. 8:19-20(2006).
//
RX   PubMed=8206680; DOI=10.1002/ijc.2910570616;
RA   Stamps A.C., Davies S.C., Burman J., O'Hare M.J.;
RT   "Analysis of proviral integration in human mammary epithelial cell
RT   lines immortalized by retroviral infection with a temperature-sensitive
RT   SV40 T-antigen construct.";
RL   Int. J. Cancer 57:865-874(1994).
//
RX   PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781;
RA   Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C.,
RA   Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.;
RT   "Molecular cytogenetic analysis of breast cancer cell lines.";
RL   Br. J. Cancer 83:1309-1317(2000).
//
RX   PubMed=12671075; DOI=10.1073/pnas.0831040100; PMCID=PMC153619;
RA   Jongeneel C.V., Iseli C., Stevenson B.J., Riggins G.J., Lal A.,
RA   Mackay A., Harris R.A., O'Hare M.J., Neville A.M., Simpson A.J.G.,
RA   Strausberg R.L.;
RT   "Comprehensive sampling of gene expression in human cell lines with
RT   massively parallel signature sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4702-4705(2003).
//
RX   PubMed=16685446; DOI=10.3892/ijo.28.6.1441;
RA   dos Santos M.L., Palanch C.G., Salaorni S., da Silva W.A. Jr.,
RA   Nagai M.A.;
RT   "Transcriptome characterization of human mammary cell lines expressing
RT   different levels of ERBB2 by serial analysis of gene expression.";
RL   Int. J. Oncol. 28:1441-1461(2006).
//