ID   CO
AC   CVCL_J653
SY   COLE; Cole; Co
DR   BioSample; SAMN03151618
DR   Cosmic; 1086354
DR   Cosmic; 1486583
DR   Wikidata; Q54813920
RX   PubMed=2602651;
RX   PubMed=2690233;
RX   PubMed=4018743;
RX   PubMed=8558920;
RX   PubMed=12581897;
RX   PubMed=12592342;
RX   PubMed=20143388;
RX   PubMed=29533902;
WW   http://iclac.org/wp-content/uploads/Cross-Contaminations_v11_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a CCRF-CEM derivative (PubMed=12581897; PubMed=12592342; PubMed=20143388). Originally thought to originate from the lymph node biopsy of a patient with Hodgkin lymphoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00186.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from sampling site: Peripheral blood. Cell type=T-cell.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 23-06-22; Version: 23
//
RX   PubMed=2602651; DOI=10.1007/978-3-642-83781-4_6;
RA   Jones D.B., Furley A.J.W., Gerdes J., Greaves M.F., Stein H.,
RA   Wright D.H.;
RT   "Phenotypic and genotypic analysis of two cell lines derived from
RT   Hodgkin's disease tissue biopsies.";
RL   Recent Results Cancer Res. 117:62-66(1989).
//
RX   PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5;
RA   Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E.,
RA   Tesch H., Fonatsch C., Stein H., Diehl V.;
RT   "Biology of Hodgkin cell lines.";
RL   Recent Results Cancer Res. 117:53-61(1989).
//
RX   PubMed=4018743; DOI=10.1002/hon.2900030205;
RA   Jones D.B., Scott C.S., Wright D.H., Stein H., Beverley P.C.L.,
RA   Payne S.V., Crawford D.H.;
RT   "Phenotypic analysis of an established cell line derived from a
RT   patient with Hodgkin's disease (HD).";
RL   Hematol. Oncol. 3:133-145(1985).
//
RX   PubMed=8558920;
RA   Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M.,
RA   Quentmeier H., Drexler H.G.;
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   PubMed=12581897; DOI=10.1016/S0165-4608(02)00656-8;
RA   Berglund M., Flordal E., Gullander J., Lui W.-O., Larsson C.,
RA   Lagercrantz S., Enblad G.;
RT   "Molecular cytogenetic characterization of four commonly used cell
RT   lines derived from Hodgkin lymphoma.";
RL   Cancer Genet. Cytogenet. 141:43-48(2003).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler H.G., Pommerenke C., Eberth S., Nagel S.;
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//