ID   RPMI-8226/MDR10V
AC   CVCL_J433
SY   8226/MDR10V; 8226/MDR(10)V; DOX-10V
DR   cancercelllines; CVCL_J433
DR   Wikidata; Q54951249
RX   PubMed=8968098;
RX   PubMed=10095106;
CC   Population: African American.
CC   Characteristics: Produces IgG lambda (from parent cell line).
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Selected for resistance to: ChEBI; CHEBI:9948; Verapamil (VPL).
CC   Sequence variation: Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_J431 ! RPMI-8226/Dox40
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 18
//
RX   PubMed=8968098;
RA   Abbaszadegan M.R., Cress A.E., Futscher B.W., Bellamy W.T.,
RA   Dalton W.S.;
RT   "Evidence for cytoplasmic P-glycoprotein location associated with
RT   increased multidrug resistance and resistance to chemosensitizers.";
RL   Cancer Res. 56:5435-5442(1996).
//
RX   PubMed=10095106; DOI=10.1016/S0378-1119(99)00042-6;
RA   Duan Z.-F., Feller A.J., Toh H.C., Makastorsis T., Seiden M.V.;
RT   "TRAG-3, a novel gene, isolated from a taxol-resistant ovarian
RT   carcinoma cell line.";
RL   Gene 229:75-81(1999).
//