ID   CEM-SS
AC   CVCL_J318
SY   CEM-ss; CEM SS; CEM_SS; CEMss; CEM-Syncitial Sensitive
DR   BEI_Resources; ARP-776
DR   cancercelllines; CVCL_J318
DR   ChEMBL-Cells; CHEMBL3307644
DR   ChEMBL-Targets; CHEMBL614548
DR   Cosmic; 1247869
DR   PubChem_Cell_line; CVCL_J318
DR   TOKU-E; 4084
DR   Wikidata; Q54809255
RX   PubMed=3481271;
RX   PubMed=25253335;
WW   Provider; NIBSC; 0048; http://www.nibsc.org/Default.aspx?pageid=597&id=0048&theme=default
CC   Population: Caucasian.
CC   Virology: Used for a quantitative syncytium-forming assay for the detection of human immunodeficiency virus-1 and -2 isolates.
CC   Doubling time: ~1-2 days (BEI_Resources=ARP-776).
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 27
//
RX   PubMed=3481271; DOI=10.1089/aid.1987.3.283;
RA   Nara P.L., Hatch W.C., Dunlop N.M., Robey W.G., Arthur L.O.,
RA   Gonda M.A., Fischinger P.J.;
RT   "Simple, rapid, quantitative, syncytium-forming microassay for the
RT   detection of human immunodeficiency virus neutralizing antibody.";
RL   AIDS Res. Hum. Retroviruses 3:283-302(1987).
//
RX   PubMed=25253335; DOI=10.1128/JVI.01543-14; PMCID=PMC4249123;
RA   Herold N., Anders-Osswein M., Glass B., Eckhardt M., Muller B.,
RA   Krausslich H.-G.;
RT   "HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at
RT   the plasma membrane and does not require endocytosis.";
RL   J. Virol. 88:13956-13970(2014).
//