ID   SK-beta2.7
AC   CVCL_J125
DR   cancercelllines; CVCL_J125
DR   Wikidata; Q54953612
RX   PubMed=8977199;
CC   Problematic cell line: Contaminated. Parent cell line (SKW-3) has been shown to be a KE-37 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2197 ! SKW-3
SX   Male
AG   27Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 14
//
RX   PubMed=8977199; DOI=10.4049/jimmunol.158.1.273;
RA   Weber K.S.C., York M.R., Springer T.A., Klickstein L.B.;
RT   "Characterization of lymphocyte function-associated antigen 1
RT   (LFA-1)-deficient T cell lines: the alphaL and beta2 subunits are
RT   interdependent for cell surface expression.";
RL   J. Immunol. 158:273-279(1997).
//