ID   USPC-ARK-11
AC   CVCL_IV82
SY   USPC-ARK11; ARK11
DR   Cosmic; 2640560
DR   Wikidata; Q54991945
RX   PubMed=23891627;
RX   PubMed=25268372;
RX   PubMed=27894751;
CC   Population: African American.
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
DI   NCIt; C27838; Endometrial serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   80Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 29-06-23; Version: 5
//
RX   PubMed=23891627; DOI=10.1016/j.ajog.2013.07.020;
RA   English, Diana P.
RA   Bellone, Stefania
RA   Cocco, Emiliano
RA   Bortolomai, Ileana
RA   Pecorelli, Sergio
RA   Lopez, Salvatore
RA   Silasi, Dan-Arin
RA   Schwartz, Peter E.
RA   Rutherford, Thomas J.
RA   Santin, Alessandro D.
RT   "Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications
RT   determine the sensitivity of uterine serous carcinoma cell lines to
RT   GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase
RT   (TORC1/2).";
RL   Am. J. Obstet. Gynecol. 209:465.e1-465.e9(2013).
//
RX   PubMed=25268372; DOI=10.1038/bjc.2014.519; PMCID=PMC4453741;
RA   Schwab, Carlton L.
RA   Bellone, Stefania
RA   English, Diana P.
RA   Roque, Dana Marie
RA   Lopez, S.
RA   Cocco, Emiliano
RA   Nicoletti, Roberta
RA   Bortolomai, Ileana
RA   Bonazzoli, Elena
RA   Ratner, Elena
RA   Silasi, Dan-Arin
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Rutherford, Thomas J.
RA   Santin, Alessandro D.
RT   "Afatinib demonstrates remarkable activity against HER2-amplified
RT   uterine serous endometrial cancer in vitro and in vivo.";
RL   Br. J. Cancer 111:1750-1756(2014).
//
RX   PubMed=27894751; DOI=10.1016/j.ygyno.2016.11.023; PMCID=PMC5183545;
RA   Bellone, Stefania
RA   Bignotti, Eliana
RA   Lonardi, Silvia
RA   Ferrari, Francesca
RA   Centritto, Floriana
RA   Masserdotti, Alice
RA   Pettinella, Francesca
RA   Black, Jonathan D.
RA   Menderes, Gulden
RA   Altwerger, Gary
RA   Hui, Pei
RA   Lopez, Salvatore
RA   de Haydu, Christopher
RA   Bonazzoli, Elena
RA   Predolini, Federica
RA   Zammataro, Luca
RA   Cocco, Emiliano
RA   Ferrari, Federico
RA   Ravaggi, Antonella
RA   Romani, Chiara
RA   Facchetti, Fabio
RA   Sartori, Enrico
RA   Odicino, Franco Edoardo
RA   Silasi, Dan-Arin
RA   Litkouhi, Babak
RA   Ratner, Elena
RA   Azodi, Masoud
RA   Schwartz, Peter E.
RA   Santin, Alessandro D.
RT   "Polymerase epsilon (POLE) ultra-mutation in uterine tumors correlates
RT   with T lymphocyte infiltration and increased resistance to
RT   platinum-based chemotherapy in vitro.";
RL   Gynecol. Oncol. 144:146-152(2017).
//