ID   PC/AA/C1/SB10
AC   CVCL_IQ06
SY   PC/AA/C1/SB/10; AA/C1/SB10
DR   IARC_TP53; 23789
DR   Wikidata; Q54938516
RX   DOI=10.1007/978-1-4612-0411-4_28;
RX   PubMed=2369746;
RX   PubMed=16465285;
CC   Selected for resistance to: ChEBI; CHEBI_64103; Sodium butyrate.
CC   Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C5673; Colorectal adenoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_IQ05 ! PC/AA/C1/SB
SX   Male
AG   34Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 19-12-24; Version: 7
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RX   DOI=10.1007/978-1-4612-0411-4_28;
RA   Williams A.C., Manning A., Harper S.J., Paraskeva C.;
RT   "Multiple steps in the in vitro immortalisation and neoplastic
RT   conversion of human colonic epithelial cells.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.281-290; Humana Press; New York; USA (1990).
//
RX   PubMed=2369746;
RA   Williams A.C., Harper S.J., Paraskeva C.;
RT   "Neoplastic transformation of a human colonic epithelial cell line: in
RT   vitro evidence for the adenoma to carcinoma sequence.";
RL   Cancer Res. 50:4724-4730(1990).
//
RX   PubMed=16465285; DOI=10.1038/sj.cdd.4400293;
RA   Butt A.J., Hague A., Paraskeva C.;
RT   "Butyrate- but not TGFbeta1-induced apoptosis of colorectal adenoma
RT   cells is associated with increased expression of the differentiation
RT   markers E-cadherin and alkaline phosphatase.";
RL   Cell Death Differ. 4:725-732(1997).
//