ID   Lec4A
AC   CVCL_IP62
SY   CHO-Lec4A; CHO Lec4A; Pro~Lec4.12-2; Pro~Lec4A.12-2; ProLec4A.12.2
DR   BTO; BTO:0005989
DR   Wikidata; Q54902426
RX   PubMed=2530238;
RX   PubMed=6295280;
RX   PubMed=8910328;
RX   PubMed=24078077;
CC   Sequence variation: Mutation; UniProtKB; P97259; Mgat5; Simple; p.Leu188Arg (c.563T>G); Zygosity=Homozygous; Note=Causes mistargeting of the protein to the ER (PubMed=8910328).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4382 ! CHO Pro-5
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 03-03-17; Last updated: 30-01-24; Version: 11
//
RX   PubMed=2530238; DOI=10.1083/jcb.109.5.2089;
RA   Chaney W.G., Sundaram S., Friedman N., Stanley P.;
RT   "The Lec4A CHO glycosylation mutant arises from
RT   miscompartmentalization of a Golgi glycosyltransferase.";
RL   J. Cell Biol. 109:2089-2096(1989).
//
RX   PubMed=6295280; DOI=10.1016/0003-9861(82)90141-2;
RA   Stanley P.;
RT   "Carbohydrate heterogeneity of vesicular stomatitis virus G
RT   glycoprotein allows localization of the defect in a glycosylation
RT   mutant of CHO cells.";
RL   Arch. Biochem. Biophys. 219:128-139(1982).
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RX   PubMed=8910328; DOI=10.1074/jbc.271.44.27462;
RA   Weinstein J., Sundaram S., Wang X.-H., Delgado D., Basu R., Stanley P.;
RT   "A point mutation causes mistargeting of Golgi GlcNAc-TV in the Lec4A
RT   Chinese hamster ovary glycosylation mutant.";
RL   J. Biol. Chem. 271:27462-27469(1996).
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RX   PubMed=24078077; DOI=10.1007/s00418-013-1146-1;
RA   Dong Z.-Z., Zuber C., Pierce M., Stanley P., Roth J.;
RT   "Reduction in Golgi apparatus dimension in the absence of a
RT   residential protein, N-acetylglucosaminyltransferase V.";
RL   Histochem. Cell Biol. 141:153-164(2014).
//