ID   BEL-7404-CP20
AC   CVCL_IP09
SY   BEL7404-CP20; 7404-CP20
DR   BTO; BTO_0006380
DR   GEO; GSM743503
DR   Wikidata; Q54795979
RX   PubMed=7710928;
RX   PubMed=9443404;
RX   PubMed=22571463;
CC   Problematic cell line: Contaminated. Ancestral cell line (BEL-7404) has been shown to be a HeLa derivative.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_IP08 ! BEL-7404-CP7.5
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 10-04-25; Version: 12
//
RX   PubMed=7710928; DOI=10.1038/bjc.1995.134; PMCID=PMC2033730;
RA   Shen, Ding-Wu
RA   Akiyama, Shin-ichi
RA   Schoenlein, Patricia V.
RA   Pastan, Ira
RA   Gottesman, Michael Marc
RT   "Characterisation of high-level cisplatin-resistant cell lines
RT   established from a human hepatoma cell line and human KB
RT   adenocarcinoma cells: cross-resistance and protein changes.";
RL   Br. J. Cancer 71:676-683(1995).
//
RX   PubMed=9443404;
RA   Shen, Ding-Wu
RA   Pastan, Ira
RA   Gottesman, Michael Marc
RT   "Cross-resistance to methotrexate and metals in human
RT   cisplatin-resistant cell lines results from a pleiotropic defect in
RT   accumulation of these compounds associated with reduced plasma
RT   membrane binding proteins.";
RL   Cancer Res. 58:268-275(1998).
//
RX   PubMed=22571463; DOI=10.1021/mp300153z; PMCID=PMC3367311;
RA   Shen, Ding-Wu
RA   Pouliot, Lynn M.
RA   Gillet, Jean-Pierre
RA   Ma, Wen-Ting
RA   Johnson, Alfred C.
RA   Hall, Matthew D.
RA   Gottesman, Michael Marc
RT   "The transcription factor GCF2 is an upstream repressor of the small
RT   GTPAse RhoA, regulating membrane protein trafficking, sensitivity to
RT   doxorubicin, and resistance to cisplatin.";
RL   Mol. Pharm. 9:1822-1833(2012).
//