ID   SKM-1/HHT
AC   CVCL_IM24
DR   cancercelllines; CVCL_IM24
DR   Wikidata; Q54954747
RX   PubMed=22967374;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:71019; Omacetaxine mepesuccinate (Homoharringtonine; HHT).
CC   Sequence variation: Mutation; HGNC; 25657; BCORL1; Simple; c.4619-1G>A; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Lys117Asn (c.351A>C); ClinVar=VCV000375965; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   NCIt; C3247; Myelodysplastic syndrome
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0098 ! SKM-1
SX   Male
AG   76Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 13
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RX   PubMed=22967374; DOI=10.3760/cma.j.issn.0253-2727.2012.06.001;
RA   Zhou F., Tan W., Ma Y., Chen B.-B., Zhu P., Xu X.-P., Lin G.-W.;
RT   "Establishment of human homoharringtonine-resistant SKM-1 cell line
RT   and its biological characteristics.";
RL   Zhonghua Xue Ye Xue Za Zhi 33:433-438(2012).
//