ID   T47D-ST3
AC   CVCL_HG15
SY   T47D 3STMYC
DR   cancercelllines; CVCL_HG15
DR   Wikidata; Q54971564
RX   PubMed=9182658;
RX   PubMed=16319059;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:10862; ST3GAL1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0553 ! T-47D
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 14-08-25; Version: 14
CH   CVCL_HG17 ! T47D-ST3-STn
//
RX   PubMed=9182658; DOI=10.1083/jcb.137.6.1229; PMCID=PMC2132526;
RA   Whitehouse, Caroline
RA   Burchell, Joy M.
RA   Gschmeissner, Stephen
RA   Brockhausen, Inka
RA   Lloyd, Kenneth Oliver
RA   Taylor-Papadimitriou, Joyce
RT   "A transfected sialyltransferase that is elevated in breast cancer and
RT   localizes to the medial/trans-Golgi apparatus inhibits the development
RT   of core-2-based O-glycans.";
RL   J. Cell Biol. 137:1229-1241(1997).
//
RX   PubMed=16319059; DOI=10.1074/jbc.M511826200;
RA   Sewell, Robert
RA   Backstrom, Malin
RA   Dalziel, Martin
RA   Gschmeissner, Stephen
RA   Karlsson, Hasse
RA   Noll, Thomas
RA   Gatgens, Jochem
RA   Clausen, Henrik
RA   Hansson, Gunnar C.
RA   Burchell, Joy M.
RA   Taylor-Papadimitriou, Joyce
RT   "The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and
RT   is responsible for the synthesis of the tumor-associated sialyl-Tn
RT   O-glycan in human breast cancer.";
RL   J. Biol. Chem. 281:3586-3594(2006).
//