ID   HCT 116 EphA2 KO Tet-inducible
AC   CVCL_HG05
DR   CancerTools; 153207
DR   Wikidata; Q54881938
DR   Ximbio; 153207
RX   PubMed=26283684;
CC   Knockout cell: Method=shRNA knockdown; HGNC; 3386; EPHA2.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from sampling site: Colon.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 23-06-22; Version: 10
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RX   PubMed=26283684; DOI=10.1158/1078-0432.CCR-15-0603;
RA   Dunne P.D., Dasgupta S., Blayney J.K., McArt D.G., Redmond K.L.,
RA   Weir J.-A., Bradley C.A., Sasazuki T., Shirasawa S., Wang T.-T.,
RA   Srivastava S., Ong C.W., Arthur K., Salto-Tellez M., Wilson R.H.,
RA   Johnston P.G., van Schaeybroeck S.;
RT   "EphA2 expression is a key driver of migration and invasion and a poor
RT   prognostic marker in colorectal cancer.";
RL   Clin. Cancer Res. 22:230-242(2016).
//