ID   HCT 116 AXL KO Tet-inducible
AC   CVCL_HG04
DR   cancercelllines; CVCL_HG04
DR   CancerTools; 153206
DR   Wikidata; Q54881912
DR   Ximbio; 153206
RX   PubMed=24170546;
CC   Population: Caucasian.
CC   Knockout cell: Method=shRNA knockdown; HGNC; HGNC:905; AXL.
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 19-12-24; Version: 14
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RX   PubMed=24170546; DOI=10.1158/1078-0432.CCR-13-1354; PMCID=PMC3885388;
RA   Dunne, Philip D.
RA   McArt, Darragh G.
RA   Blayney, Jaine Katharine
RA   Kalimutho, Murugan
RA   Greer, Samanda
RA   Wang, Ting-Ting
RA   Srivastava, Supriya
RA   Ong, Chee Wee
RA   Arthur, Ken
RA   Loughrey, Maurice
RA   Redmond, Keara L.
RA   Longley, Daniel B.
RA   Salto-Tellez, Manuel
RA   Johnston, Patrick Gerard
RA   van Schaeybroeck, Sandra
RT   "AXL is a key regulator of inherent and chemotherapy-induced invasion
RT   and predicts a poor clinical outcome in early-stage colon cancer.";
RL   Clin. Cancer Res. 20:164-175(2014).
//