ID   Tet2
AC   CVCL_HF70
SY   TET2; SHEP-2; SHEP2
DR   cancercelllines; CVCL_HF70
DR   GEO; GSM692875
DR   Wikidata; Q54972194
RX   PubMed=8761302;
RX   PubMed=17506115;
RX   PubMed=22213050;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2A38 ! SHEP-SF
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 10-04-25; Version: 14
//
RX   PubMed=8761302;
RA   Lutz W., Stohr M., Schurmann J., Wenzel A., Lohr A., Schwab M.;
RT   "Conditional expression of N-myc in human neuroblastoma cells
RT   increases expression of alpha-prothymosin and ornithine decarboxylase
RT   and accelerates progression into S-phase early after mitogenic
RT   stimulation of quiescent cells.";
RL   Oncogene 13:803-812(1996).
//
RX   PubMed=17506115; DOI=10.1002/nbm.1181;
RA   Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A.,
RA   Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.;
RT   "1H MRS identifies specific metabolite profiles associated with
RT   MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell
RT   lines.";
RL   NMR Biomed. 20:692-700(2007).
//
RX   PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132;
RA   Gawecka J.E., Geerts D., Koster J., Caliva M.J., Sulzmaier F.J.,
RA   Opoku-Ansah J., Wada R.K., Bachmann A.S., Ramos J.W.;
RT   "PEA15 impairs cell migration and correlates with clinical features
RT   predicting good prognosis in neuroblastoma.";
RL   Int. J. Cancer 131:1556-1568(2012).
//