ID   HCT 116 PDPK1(+/-)
AC   CVCL_HD87
SY   PDPK1 (+/-) HCT116
DR   cancercelllines; CVCL_HD87
DR   Horizon_Discovery; HD+R02-080
DR   Wikidata; Q54881973
RX   PubMed=20133737;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:8816; PDPK1 (Note=1 of 2 alleles).
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 19-12-24; Version: 14
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RX   PubMed=20133737; DOI=10.1073/pnas.0914018107; PMCID=PMC2823889;
RA   Ericson, Kajsa
RA   Gan, Christine
RA   Cheong, Ian
RA   Rago, Carlo
RA   Samuels, Yardena
RA   Velculescu, Victor E.
RA   Kinzler, Kenneth Wayne
RA   Huso, David L.
RA   Vogelstein, Bert
RA   Papadopoulos, Nickolas
RT   "Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal
RT   cancer cells clarifies their roles in tumor growth regulation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:2598-2603(2010).
//