ID   HCT 116 KRAS(+/-)
AC   CVCL_HD81
SY   KRAS (+/-) HCT116
DR   cancercelllines; CVCL_HD81
DR   Horizon_Discovery; HD+104-008
DR   Wikidata; Q54881959
RX   PubMed=19661383;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:6407; KRAS (Note=1 of 2 alleles).
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 19-12-24; Version: 14
//
RX   PubMed=19661383; DOI=10.1126/science.1174229; PMCID=PMC2820374;
RA   Yun, Jiyeon
RA   Rago, Carlo
RA   Cheong, Ian
RA   Pagliarini, Raymond
RA   Angenendt, Philipp
RA   Rajagopalan, Harith
RA   Schmidt, Kerstin
RA   Willson, James K.V.
RA   Markowitz, Sanford David
RA   Zhou, Shi-Bin
RA   Diaz, Luis Alberto Jr.
RA   Velculescu, Victor E.
RA   Lengauer, Christoph
RA   Kinzler, Kenneth Wayne
RA   Vogelstein, Bert
RA   Papadopoulos, Nickolas
RT   "Glucose deprivation contributes to the development of KRAS pathway
RT   mutations in tumor cells.";
RL   Science 325:1555-1559(2009).
//