ID   DLD-1 KRAS(+/-) 1
AC   CVCL_HD62
SY   KRAS (+/-) DLD-1
DR   Horizon_Discovery; HD+105-002
DR   Wikidata; Q54831162
RX   PubMed=19661383;
CC   Population: Caucasian.
CC   Characteristics: In DLD-1 one of the two KRAS alleles has a p.Gly13Asp mutation. This cell line is KO for the mutant allele.
CC   Knockout cell: Method=Homologous recombination; HGNC; 6407; KRAS (Note=1 of 2 alleles).
CC   Miscellaneous: Horizon distributes two DLD-1 KRAS(+/-) cell lines, one developed internally (Cellosaurus=CVCL_HE28) and one originating from the group of Volgenstein (Cellosaurus=CVCL_HD62).
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0248 ! DLD-1
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 30-01-24; Version: 7
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RX   PubMed=19661383; DOI=10.1126/science.1174229;
RA   Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P.,
RA   Rajagopalan H., Schmidt K., Willson J.K.V., Markowitz S.D., Zhou S.-B.,
RA   Diaz L.A. Jr., Velculescu V.E., Lengauer C., Kinzler K.W.,
RA   Vogelstein B., Papadopoulos N.;
RT   "Glucose deprivation contributes to the development of KRAS pathway
RT   mutations in tumor cells.";
RL   Science 325:1555-1559(2009).
//