ID   AG01522
AC   CVCL_H759
SY   AG-1522; AG 1522; AG1522; AG01522B; AGO 1522; AGO1522; AG1522D; 1522
DR   CLO; CLO_0036902
DR   Coriell; AG01522
DR   GEO; GSE93860
DR   GEO; GSM520723
DR   GEO; GSM520724
DR   GEO; GSM520725
DR   GEO; GSM520726
DR   GEO; GSM520727
DR   GEO; GSM520728
DR   GEO; GSM520729
DR   GEO; GSM520730
DR   GEO; GSM520731
DR   GEO; GSM520732
DR   NCBI_Iran; C449
DR   Wikidata; Q54609458
RX   CelloPub=CLPUB00387;
RX   CelloPub=CLPUB00597;
RX   DOI=10.5962/bhl.title.4090;
RX   PubMed=1574572;
RX   PubMed=1845955;
RX   PubMed=2380097;
RX   PubMed=2559742;
RX   PubMed=2897722;
RX   PubMed=2973075;
RX   PubMed=3182330;
RX   PubMed=6148444;
RX   PubMed=6442144;
RX   PubMed=6810166;
RX   PubMed=6843573;
RX   PubMed=7104995;
RX   PubMed=7253718;
RX   PubMed=7329430;
RX   PubMed=7374661;
RX   PubMed=7471105;
RX   PubMed=19896956;
RX   PubMed=21149446;
RX   PubMed=28248986;
WW   Info; -; -; http://faculty.washington.edu/trawets/archive/Human/fibroblast/ag1522/index.html
CC   Group: Space-flown cell line (cellonaut).
CC   Anecdotal: Have been flown in space on the ISS to study growth in microgravity (PubMed=28248986).
CC   Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
CC   Cell type: Fibroblast of foreskin; CL=CL_1001608.
ST   Source(s): NCBI_Iran=C449
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 9,10
ST   D16S539: 10
ST   D18S51: 12
ST   D21S11: 29,30
ST   D5S818: 10
ST   D7S820: 15
ST   D8S1179: 12,14
ST   FGA: 20,25
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   3D
CA   Finite cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 24
//
RX   PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3;
RA   Schwartz, Jeffrey L.
RA   Rotmensch, Jacob
RA   Giovanazzi, Susan
RA   Cohen, Marvin B.
RA   Weichselbaum, Ralph R.
RT   "Faster repair of DNA double-strand breaks in radioresistant human
RT   tumor cells.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988).
//
RX   PubMed=6843573; DOI=10.1016/0027-5107(83)90054-4;
RA   Nagasawa, Hatsumi
RA   Little, John Bertram
RT   "Comparison of kinetics of X-ray-induced cell killing in normal,
RT   ataxia telangiectasia and hereditary retinoblastoma fibroblasts.";
RL   Mutat. Res. 109:297-308(1983).
//
RX   CelloPub=CLPUB00387;
RA   Coriell, Lewis Lemon
RA   Greene, Arthur E.
RA   Mulivor, Richard A.
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 7th edition. October 1980.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.) NIH 80-2011; pp.1-254; National Institutes of Health; Bethesda; USA (1980).
//
RX   PubMed=2973075; DOI=10.2307/3577479;
RA   Fertil, Bernard
RA   Deschavanne, Patrick J.
RA   Debieu, Danielle
RA   Malaise, Edmond-Philippe
RT   "Correlation between PLD repair capacity and the survival curve of
RT   human fibroblasts in exponential growth phase: analysis in terms of
RT   several parameters.";
RL   Radiat. Res. 116:74-88(1988).
//
RX   PubMed=28248986; DOI=10.1371/journal.pone.0170358; PMCID=PMC5332164;
RA   Lu, Tao
RA   Zhang, Ye
RA   Kidane, Yared
RA   Feiveson, Alan Harold
RA   Stodieck, Louis S.
RA   Karouia, Fathi
RA   Ramesh, Govindarajan
RA   Rohde, Larry
RA   Wu, Hong-Lu
RT   "Cellular responses and gene expression profile changes due to
RT   bleomycin-induced DNA damage in human fibroblasts in space.";
RL   PLoS ONE 12:e0170358.1-e0170358.19(2017).
//
RX   PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8;
RA   Hallahan, Dennis E.
RA   Beckett, Michael A.
RA   Kufe, Donald William
RA   Weichselbaum, Ralph R.
RT   "The interaction between recombinant human tumor necrosis factor and
RT   radiation in 13 human tumor cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990).
//
RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda; USA (1994).
//
RX   PubMed=7253718; DOI=10.1016/0047-6374(81)90027-0;
RA   Das, Nirmal K.
RA   Murphy, Donald G.
RT   "The National Institute on Aging repository cell cultures.";
RL   Mech. Ageing Dev. 16:1-17(1981).
//
RX   PubMed=1845955;
RA   Samuels, Brian L.
RA   Murray, Judith L.
RA   Cohen, Marvin B.
RA   Safa, Ahmad R.
RA   Sinha, Birandra K.
RA   Townsend, Alan J.
RA   Beckett, Michael A.
RA   Weichselbaum, Ralph R.
RT   "Increased glutathione peroxidase activity in a human sarcoma cell
RT   line with inherent doxorubicin resistance.";
RL   Cancer Res. 51:521-527(1991).
//
RX   DOI=10.5962/bhl.title.4090;
RA   Coriell, Lewis Lemon
RA   Greene, Arthur E.
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 4th edition. October 1977.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda; USA (1977).
//
RX   PubMed=2897722; DOI=10.1002/tcm.1770080104;
RA   Nagasawa, Hatsumi
RA   Burke, Maureen J.
RA   Little, Frederic Fletcher
RA   McCone, Ellen F.
RA   Chan, Gerald L.
RA   Little, John Bertram
RT   "Multiple abnormalities in the ultraviolet light response of cultured
RT   fibroblasts derived from patients with the basal cell nevus syndrome.";
RL   Teratog. Carcinog. Mutagen. 8:25-33(1988).
//
RX   PubMed=1574572; DOI=10.2307/3578273;
RA   Dunphy, Edward J.
RA   Beckett, Michael A.
RA   Thompson, Lawrence H.
RA   Weichselbaum, Ralph R.
RT   "Expression of the polymorphic human DNA repair gene XRCC1 does not
RT   correlate with radiosensitivity in the cells of human head and neck
RT   tumor cell lines.";
RL   Radiat. Res. 130:166-170(1992).
//
RX   PubMed=19896956; DOI=10.1016/j.mrfmmm.2009.10.013;
RA   Wilson, Paul F.
RA   Nham, Peter B.
RA   Urbin, Salustra S.
RA   Hinz, John M.
RA   Jones, Irene M.
RA   Thompson, Lawrence H.
RT   "Inter-individual variation in DNA double-strand break repair in human
RT   fibroblasts before and after exposure to low doses of ionizing
RT   radiation.";
RL   Mutat. Res. 683:91-97(2010).
//
RX   PubMed=7471105;
RA   Weichselbaum, Ralph R.
RA   Nove, John
RA   Little, John Bertram
RT   "X-ray sensitivity of fifty-three human diploid fibroblast cell
RT   strains from patients with characterized genetic disorders.";
RL   Cancer Res. 40:920-925(1980).
//
RX   PubMed=7104995;
RA   Kinsella, Timothy James
RA   Mitchell, James B.
RA   McPherson, Scott
RA   Russo, Angelo
RA   Tietze, Frank
RT   "In vitro X-ray sensitivity in ataxia telangiectasis homozygote and
RT   heterozygote skin fibroblasts under oxic and hypoxic conditions.";
RL   Cancer Res. 42:3950-3956(1982).
//
RX   PubMed=21149446; DOI=10.1074/jbc.M110.204065; PMCID=PMC3059052;
RA   Kozlov, Sergei V.
RA   Graham, Mark E.
RA   Jakob, Burkhard
RA   Tobias, Frank
RA   Kijas, Amanda W.
RA   Tanuji, Marcel
RA   Chen, Philip
RA   Robinson, Phillip James
RA   Taucher-Scholz, Gisela
RA   Suzuki, Keiji
RA   So, Sairai
RA   Chen, David
RA   Lavin, Martin Francis
RT   "Autophosphorylation and ATM activation: additional sites add to the
RT   complexity.";
RL   J. Biol. Chem. 286:9107-9119(2011).
//
RX   PubMed=7329430; DOI=10.1016/0027-5107(81)90059-2;
RA   Nove, John
RA   Nichols, Warren W.
RA   Weichselbaum, Ralph R.
RA   Little, John Bertram
RT   "Abnormalities of human chromosome 13 and in vitro radiosensitivity; a
RT   study of 19 fibroblast strains.";
RL   Mutat. Res. 84:157-167(1981).
//
RX   PubMed=7374661; DOI=10.1016/0027-5107(80)90164-5;
RA   Little, John Bertram
RA   Nove, John
RA   Weichselbaum, Ralph R.
RT   "Abnormal sensitivity of diploid skin fibroblasts from a family with
RT   Gardner's syndrome to the lethal effects of X-irradiation, ultraviolet
RT   light and mitomycin-C.";
RL   Mutat. Res. 70:241-250(1980).
//
RX   PubMed=6810166; DOI=10.1016/0027-5107(82)90299-8;
RA   Barfknecht, Thomas R.
RA   Little, John Bertram
RT   "Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA
RT   alkylating agents.";
RL   Mutat. Res. 94:369-382(1982).
//
RX   PubMed=6442144; DOI=10.1007/978-1-4684-4892-4_20;
RA   Nagasawa, Hatsumi
RA   Little, Frederic Fletcher
RA   Burke, Maureen J.
RA   McCone, Ellen F.
RA   Targovnik, Harris S.
RA   Chan, Gerald L.
RA   Little, John Bertram
RT   "Study of basal cell nevus syndrome fibroblasts after treatment with
RT   DNA-damaging agents.";
RL   Basic Life Sci. 29:775-785(1984).
//
RX   PubMed=6148444; DOI=10.1093/jnci/73.4.801;
RA   Morstyn, George
RA   Russo, Angelo
RA   Carney, Desmond Niall
RA   Karawya, Essam
RA   Wilson, Samuel H. Jr.
RA   Mitchell, James B.
RT   "Heterogeneity in the radiation survival curves and biochemical
RT   properties of human lung cancer cell lines.";
RL   J. Natl. Cancer Inst. 73:801-807(1984).
//
RX   PubMed=2559742; DOI=10.1002/mc.2940020606;
RA   Kano, Yoshio
RA   Little, John Bertram
RT   "Efficient immortalization by SV40 T DNA of skin fibroblasts from
RT   patients with Wilms' tumor associated with chromosome 11p deletion.";
RL   Mol. Carcinog. 2:314-321(1989).
//