ID   AG01522
AC   CVCL_H759
SY   AG-1522; AG 1522; AG1522; AG01522B; AGO 1522; AGO1522; AG1522D; 1522
DR   CLO; CLO_0036902
DR   Coriell; AG01522
DR   GEO; GSE93860
DR   GEO; GSM520723
DR   GEO; GSM520724
DR   GEO; GSM520725
DR   GEO; GSM520726
DR   GEO; GSM520727
DR   GEO; GSM520728
DR   GEO; GSM520729
DR   GEO; GSM520730
DR   GEO; GSM520731
DR   GEO; GSM520732
DR   NCBI_Iran; C449
DR   Wikidata; Q54609458
RX   CelloPub=CLPUB00387;
RX   CelloPub=CLPUB00597;
RX   DOI=10.5962/bhl.title.4090;
RX   PubMed=1574572;
RX   PubMed=1845955;
RX   PubMed=2380097;
RX   PubMed=2559742;
RX   PubMed=2897722;
RX   PubMed=2973075;
RX   PubMed=3182330;
RX   PubMed=6148444;
RX   PubMed=6442144;
RX   PubMed=6810166;
RX   PubMed=6843573;
RX   PubMed=7104995;
RX   PubMed=7253718;
RX   PubMed=7329430;
RX   PubMed=7374661;
RX   PubMed=7471105;
RX   PubMed=19896956;
RX   PubMed=21149446;
RX   PubMed=28248986;
CC   Group: Space-flown cell line (cellonaut).
CC   Anecdotal: Have been flown in space on the ISS to study growth in microgravity (PubMed=28248986).
CC   Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
CC   Cell type: Fibroblast of foreskin; CL=CL_1001608.
ST   Source(s): NCBI_Iran
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 9,10
ST   D16S539: 10
ST   D18S51: 12
ST   D21S11: 29,30
ST   D5S818: 10
ST   D7S820: 15
ST   D8S1179: 12,14
ST   FGA: 20,25
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   3D
CA   Finite cell line
DT   Created: 11-02-13; Last updated: 29-06-23; Version: 22
RX   CelloPub=CLPUB00387;
RA   Coriell L.L., Greene A.E., Mulivor R.A.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 7th edition. October 1980.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 80-2011; pp.1-254; National Institutes of Health; Bethesda (1980).
RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda (1994).
RX   DOI=10.5962/bhl.title.4090;
RA   Coriell L.L., Greene A.E.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 4th edition. October 1977.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda (1977).
RX   PubMed=1574572; DOI=10.2307/3578273;
RA   Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.;
RT   "Expression of the polymorphic human DNA repair gene XRCC1 does not
RT   correlate with radiosensitivity in the cells of human head and neck
RT   tumor cell lines.";
RL   Radiat. Res. 130:166-170(1992).
RX   PubMed=1845955;
RA   Samuels B.L., Murray J.L., Cohen M.B., Safa A.R., Sinha B.K.,
RA   Townsend A.J., Beckett M.A., Weichselbaum R.R.;
RT   "Increased glutathione peroxidase activity in a human sarcoma cell
RT   line with inherent doxorubicin resistance.";
RL   Cancer Res. 51:521-527(1991).
RX   PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8;
RA   Hallahan D.E., Beckett M.A., Kufe D.W., Weichselbaum R.R.;
RT   "The interaction between recombinant human tumor necrosis factor and
RT   radiation in 13 human tumor cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990).
RX   PubMed=2559742; DOI=10.1002/mc.2940020606;
RA   Kano Y., Little J.B.;
RT   "Efficient immortalization by SV40 T DNA of skin fibroblasts from
RT   patients with Wilms' tumor associated with chromosome 11p deletion.";
RL   Mol. Carcinog. 2:314-321(1989).
RX   PubMed=2897722; DOI=10.1002/tcm.1770080104;
RA   Nagasawa H., Burke M.J., Little F.F., McCone E.F., Chan G.L.,
RA   Little J.B.;
RT   "Multiple abnormalities in the ultraviolet light response of cultured
RT   fibroblasts derived from patients with the basal cell nevus syndrome.";
RL   Teratog. Carcinog. Mutagen. 8:25-33(1988).
RX   PubMed=2973075; DOI=10.2307/3577479;
RA   Fertil B., Deschavanne P.J., Debieu D., Malaise E.-P.;
RT   "Correlation between PLD repair capacity and the survival curve of
RT   human fibroblasts in exponential growth phase: analysis in terms of
RT   several parameters.";
RL   Radiat. Res. 116:74-88(1988).
RX   PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3;
RA   Schwartz J.L., Rotmensch J., Giovanazzi S., Cohen M.B.,
RA   Weichselbaum R.R.;
RT   "Faster repair of DNA double-strand breaks in radioresistant human
RT   tumor cells.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988).
RX   PubMed=6148444; DOI=10.1093/jnci/73.4.801;
RA   Morstyn G., Russo A., Carney D.N., Karawya E., Wilson S.H.,
RA   Mitchell J.B.;
RT   "Heterogeneity in the radiation survival curves and biochemical
RT   properties of human lung cancer cell lines.";
RL   J. Natl. Cancer Inst. 73:801-807(1984).
RX   PubMed=6442144; DOI=10.1007/978-1-4684-4892-4_20;
RA   Nagasawa H., Little F.F., Burke M.J., McCone E.F., Targovnik H.S.,
RA   Chan G.L., Little J.B.;
RT   "Study of basal cell nevus syndrome fibroblasts after treatment with
RT   DNA-damaging agents.";
RL   Basic Life Sci. 29:775-785(1984).
RX   PubMed=6810166; DOI=10.1016/0027-5107(82)90299-8;
RA   Barfknecht T.R., Little J.B.;
RT   "Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA
RT   alkylating agents.";
RL   Mutat. Res. 94:369-382(1982).
RX   PubMed=6843573; DOI=10.1016/0027-5107(83)90054-4;
RA   Nagasawa H., Little J.B.;
RT   "Comparison of kinetics of X-ray-induced cell killing in normal,
RT   ataxia telangiectasia and hereditary retinoblastoma fibroblasts.";
RL   Mutat. Res. 109:297-308(1983).
RX   PubMed=7104995;
RA   Kinsella T.J., Mitchell J.B., McPherson S., Russo A., Tietze F.;
RT   "In vitro X-ray sensitivity in ataxia telangiectasis homozygote and
RT   heterozygote skin fibroblasts under oxic and hypoxic conditions.";
RL   Cancer Res. 42:3950-3956(1982).
RX   PubMed=7253718; DOI=10.1016/0047-6374(81)90027-0;
RA   Das N.K., Murphy D.G.;
RT   "The National Institute on Aging repository cell cultures.";
RL   Mech. Ageing Dev. 16:1-17(1981).
RX   PubMed=7329430; DOI=10.1016/0027-5107(81)90059-2;
RA   Nove J., Nichols W.W., Weichselbaum R.R., Little J.B.;
RT   "Abnormalities of human chromosome 13 and in vitro radiosensitivity; a
RT   study of 19 fibroblast strains.";
RL   Mutat. Res. 84:157-167(1981).
RX   PubMed=7374661; DOI=10.1016/0027-5107(80)90164-5;
RA   Little J.B., Nove J., Weichselbaum R.R.;
RT   "Abnormal sensitivity of diploid skin fibroblasts from a family with
RT   Gardner's syndrome to the lethal effects of X-irradiation, ultraviolet
RT   light and mitomycin-C.";
RL   Mutat. Res. 70:241-250(1980).
RX   PubMed=7471105;
RA   Weichselbaum R.R., Nove J., Little J.B.;
RT   "X-ray sensitivity of fifty-three human diploid fibroblast cell
RT   strains from patients with characterized genetic disorders.";
RL   Cancer Res. 40:920-925(1980).
RX   PubMed=19896956; DOI=10.1016/j.mrfmmm.2009.10.013;
RA   Wilson P.F., Nham P.B., Urbin S.S., Hinz J.M., Jones I.M.,
RA   Thompson L.H.;
RT   "Inter-individual variation in DNA double-strand break repair in human
RT   fibroblasts before and after exposure to low doses of ionizing
RT   radiation.";
RL   Mutat. Res. 683:91-97(2010).
RX   PubMed=21149446; DOI=10.1074/jbc.M110.204065;
RA   Kozlov S.V., Graham M.E., Jakob B., Tobias F., Kijas A.W., Tanuji M.,
RA   Chen P., Robinson P.J., Taucher-Scholz G., Suzuki K., So S., Chen D.,
RA   Lavin M.F.;
RT   "Autophosphorylation and ATM activation: additional sites add to the
RT   complexity.";
RL   J. Biol. Chem. 286:9107-9119(2011).
RX   PubMed=28248986; DOI=10.1371/journal.pone.0170358;
RA   Lu T., Zhang Y., Kidane Y., Feiveson A., Stodieck L., Karouia F.,
RA   Ramesh G., Rohde L., Wu H.-L.;
RT   "Cellular responses and gene expression profile changes due to
RT   bleomycin-induced DNA damage in human fibroblasts in space.";
RL   PLoS ONE 12:E0170358-E0170358(2017).