ID   BE-NQ7
AC   CVCL_H585
SY   BE-NQ
DR   ChEMBL-Cells; CHEMBL3307688
DR   ChEMBL-Targets; CHEMBL614702
DR   PubChem_Cell_line; CVCL_H585
DR   Wikidata; Q54795861
RX   PubMed=9865924;
RX   PubMed=11377380;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2874; NQO1.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_H580 ! BE [Human colon carcinoma]
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 13
//
RX   PubMed=9865924;
RA   Winski, Shannon Lee
RA   Hargreaves, Robert H.J.
RA   Butler, John
RA   Ross, David
RT   "A new screening system for NAD(P)H:quinone oxidoreductase
RT   (NQO1)-directed antitumor quinones: identification of a new
RT   aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.";
RL   Clin. Cancer Res. 4:3083-3088(1998).
//
RX   PubMed=11377380; DOI=10.1016/S0006-2952(01)00631-1;
RA   Winski, Shannon Lee
RA   Swann, Elizabeth
RA   Hargreaves, Robert H.J.
RA   Dehn, Donna L.
RA   Butler, John
RA   Moody, Christopher J.
RA   Ross, David
RT   "Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels
RT   in a series of stably transfected cell lines and susceptibility to
RT   antitumor quinones.";
RL   Biochem. Pharmacol. 61:1509-1516(2001).
//