ID   BE [Human colon carcinoma]
AC   CVCL_H580
DR   cancercelllines; CVCL_H580
DR   ChEMBL-Cells; CHEMBL3307709
DR   ChEMBL-Targets; CHEMBL614798
DR   Cosmic; 724835
DR   GEO; GSM1374398
DR   GEO; GSM1374399
DR   PubChem_Cell_line; CVCL_H580
DR   Wikidata; Q54795836
RX   PubMed=626984;
RX   PubMed=1737339;
RX   PubMed=6256643;
RX   PubMed=9865924;
RX   PubMed=12068308;
RX   PubMed=22282976;
CC   Part of: KuDOS 95 cell line panel.
CC   From: Giovanella, Beppino Carlo; St. Joseph's Hospital Cancer Research Laboratory; Houston; USA.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Unspecified (PubMed=12068308).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (PubMed=12068308).
CC   Omics: Transcriptomics; Microarray.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 14-08-25; Version: 18
CH   CVCL_H581 ! BE-NQ2
CH   CVCL_H582 ! BE-NQ3
CH   CVCL_H583 ! BE-NQ4
CH   CVCL_H584 ! BE-NQ5
CH   CVCL_H585 ! BE-NQ7
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies, Helen R.
RA   Bignell, Graham Robert
RA   Cox, Charles
RA   Stephens, Philip J.
RA   Edkins, Sarah
RA   Clegg, Sheila
RA   Teague, Jon W.
RA   Woffendin, Hayley
RA   Garnett, Mathew J.
RA   Bottomley, William
RA   Davis, Neil
RA   Dicks, Ed
RA   Ewing, Rebecca
RA   Floyd, Yvonne
RA   Gray, Kristian
RA   Hall, Sarah
RA   Hawes, Rachel
RA   Hughes, Jaime
RA   Kosmidou, Vivian
RA   Menzies, Andrew
RA   Mould, Catherine
RA   Parker, Adrian
RA   Stevens, Claire
RA   Watt, Stephen
RA   Hooper, Steven
RA   Wilson, Rebecca
RA   Jayatilake, Hiran
RA   Gusterson, Barry Austin
RA   Cooper, Colin S.
RA   Shipley, Janet M.
RA   Hargrave, Darren
RA   Pritchard-Jones, Kathryn
RA   Maitland, Norman J.
RA   Chenevix-Trench, Georgia
RA   Riggins, Gregory J.
RA   Bigner, Darell Doty
RA   Palmieri, Giuseppe
RA   Cossu, Antonio
RA   Flanagan, Adrienne Margaret
RA   Nicholson, Andrew
RA   Ho, Judy W.C.
RA   Leung, Suet Yi
RA   Yuen, Siu Tsan
RA   Weber, Barbara L.
RA   Seigler, Hilliard Foster
RA   Darrow, Timothy L.
RA   Paterson, Hugh F.
RA   Marais, Richard
RA   Marshall, Christopher John
RA   Wooster, Richard
RA   Stratton, Michael Rudolf
RA   Futreal, P. Andrew
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=1737339;
RA   Traver, Robert D.
RA   Horikoshi, Tetsuro
RA   Danenberg, Kathleen D.
RA   Stadlbauer, Thomas H.W.
RA   Danenberg, Peter V.
RA   Ross, David
RA   Gibson, Neil W.
RT   "NAD(P)H:quinone oxidoreductase gene expression in human colon
RT   carcinoma cells: characterization of a mutation which modulates
RT   DT-diaphorase activity and mitomycin sensitivity.";
RL   Cancer Res. 52:797-802(1992).
//
RX   PubMed=9865924;
RA   Winski, Shannon Lee
RA   Hargreaves, Robert H.J.
RA   Butler, John
RA   Ross, David
RT   "A new screening system for NAD(P)H:quinone oxidoreductase
RT   (NQO1)-directed antitumor quinones: identification of a new
RT   aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.";
RL   Clin. Cancer Res. 4:3083-3088(1998).
//
RX   PubMed=626984;
RA   Erickson, Leonard C.
RA   Osieka, Rainhardt
RA   Kohn, Kurt W.
RT   "Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-
RT   nitrosourea-induced DNA damage in two human colon tumor cell lines.";
RL   Cancer Res. 38:802-808(1978).
//
RX   PubMed=6256643; DOI=10.1038/288724a0;
RA   Day, Rufus S. 3rd
RA   Ziolkowski, Chuck H.J.
RA   Scudiero, Dominic A.
RA   Meyer, Sharon A.
RA   Lubiniecki, Anthony S.
RA   Girardi, Anthony Joseph
RA   Galloway, Sheila Margaret
RA   Bynum, Gaither D.
RT   "Defective repair of alkylated DNA by human tumour and
RT   SV40-transformed human cell strains.";
RL   Nature 288:724-727(1980).
//
RX   PubMed=22282976; DOI=10.1093/carcin/1.1.21;
RA   Day, Rufus S. 3rd
RA   Ziolkowski, Chuck H.J.
RA   Scudiero, Dominic A.
RA   Meyer, Sharon A.
RA   Mattern, Michael R.
RT   "Human tumor cell strains defective in the repair of alkylation
RT   damage.";
RL   Carcinogenesis 1:21-32(1980).
//