ID   HT-29/CPT
AC   CVCL_H269
SY   HT-29 / CPT
DR   cancercelllines; CVCL_H269
DR   CGH-DB; 9103-4
DR   Wikidata; Q54896529
RX   PubMed=2170010;
RX   PubMed=2174738;
RX   PubMed=14973057;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_27656; Camptothecin (CPT).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 23
//
RX   PubMed=2170010;
RA   Sugimoto, Yoshikazu
RA   Tsukahara, Satomi
RA   Oh-hara, Tomoko
RA   Isoe, Toshiyuki
RA   Tsuruo, Takashi
RT   "Decreased expression of DNA topoisomerase I in camptothecin-resistant
RT   tumor cell lines as determined by a monoclonal antibody.";
RL   Cancer Res. 50:6925-6930(1990).
//
RX   PubMed=2174738;
RA   Sugimoto, Yoshikazu
RA   Tsukahara, Satomi
RA   Oh-hara, Tomoko
RA   Liu, Leroy Fong
RA   Tsuruo, Takashi
RT   "Elevated expression of DNA topoisomerase II in camptothecin-resistant
RT   human tumor cell lines.";
RL   Cancer Res. 50:7962-7965(1990).
//
RX   PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2;
RA   Yasui, Kohichiroh
RA   Mihara, Saori
RA   Zhao, Chen
RA   Okamoto, Hiroyuki
RA   Saito-Ohara, Fumiko
RA   Tomida, Akihiro
RA   Funato, Tadao
RA   Yokomizo, Akira
RA   Naito, Seiji
RA   Imoto, Issei
RA   Tsuruo, Takashi
RA   Inazawa, Johji
RT   "Alteration in copy numbers of genes as a mechanism for acquired drug
RT   resistance.";
RL   Cancer Res. 64:1403-1410(2004).
//