ID   St-4
AC   CVCL_H265
DR   ChEMBL-Cells; CHEMBL3307553
DR   ChEMBL-Targets; CHEMBL614166
DR   Cosmic; 1436022
DR   IARC_TP53; 21647
DR   PubChem_Cell_line; CVCL_H265
DR   Wikidata; Q54955732
RX   PubMed=2170010;
RX   PubMed=15767549;
RX   PubMed=15900046;
RX   PubMed=22336246;
CC   Part of: JFCR39 cancer cell line panel.
CC   Part of: JFCR45 cancer cell line panel.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr205del (c.613_615delTAT); Zygosity=Unspecified (PubMed=15900046).
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C4911; Gastric carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 29-06-23; Version: 16
RX   PubMed=2170010;
RA   Sugimoto Y., Tsukahara S., Oh-hara T., Isoe T., Tsuruo T.;
RT   "Decreased expression of DNA topoisomerase I in camptothecin-resistant
RT   tumor cell lines as determined by a monoclonal antibody.";
RL   Cancer Res. 50:6925-6930(1990).
RX   PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234;
RA   Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y.,
RA   Yamori T.;
RT   "Chemosensitivity profile of cancer cell lines and identification of
RT   genes determining chemosensitivity by an integrated bioinformatical
RT   approach using cDNA arrays.";
RL   Mol. Cancer Ther. 4:399-412(2005).
RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
RA   Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y.,
RA   Yamazaki K., Hamada J., Tada M., Moriuchi T., Ishikawa Y., Kato Y.,
RA   Tomoda H., Yamori T., Tsuruo T.;
RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
RT   new therapeutic target.";
RL   J. Natl. Cancer Inst. 97:765-777(2005).
RX   PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017;
RA   Kong D., Yamori T.;
RT   "JFCR39, a panel of 39 human cancer cell lines, and its application in
RT   the discovery and development of anticancer drugs.";
RL   Bioorg. Med. Chem. 20:1947-1951(2012).