ID   St-4
AC   CVCL_H265
DR   ChEMBL-Cells; CHEMBL3307553
DR   ChEMBL-Targets; CHEMBL614166
DR   Cosmic; 1436022
DR   IARC_TP53; 21647
DR   PubChem_Cell_line; CVCL_H265
DR   Wikidata; Q54955732
RX   PubMed=2170010;
RX   PubMed=15767549;
RX   PubMed=15900046;
RX   PubMed=22336246;
CC   Part of: JFCR39 cancer cell line panel.
CC   Part of: JFCR45 cancer cell line panel.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr205del (c.613_615delTAT); Zygosity=Unspecified (PubMed=15900046).
CC   Omics: Transcriptomics; Microarray.
DI   NCIt; C4911; Gastric carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 18
CH   CVCL_Y176 ! St-4/cDDP
CH   CVCL_H266 ! St-4/CPT
//
RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
RA   Mashima, Tetsuo
RA   Oh-hara, Tomoko
RA   Sato, Shigeo
RA   Mochizuki, Mikiko
RA   Sugimoto, Yoshikazu
RA   Yamazaki, Kanami
RA   Hamada, Jun-ichi
RA   Tada, Mitsuhiro
RA   Moriuchi, Tetsuya
RA   Ishikawa, Yuichi
RA   Kato, Yo
RA   Tomoda, Hiroshi
RA   Yamori, Takao
RA   Tsuruo, Takashi
RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
RT   new therapeutic target.";
RL   J. Natl. Cancer Inst. 97:765-777(2005).
//
RX   PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234;
RA   Nakatsu, Noriyuki
RA   Yoshida, Yoko
RA   Yamazaki, Kanami
RA   Nakamura, Tomoki
RA   Dan, Shingo
RA   Fukui, Yasuhisa
RA   Yamori, Takao
RT   "Chemosensitivity profile of cancer cell lines and identification of
RT   genes determining chemosensitivity by an integrated bioinformatical
RT   approach using cDNA arrays.";
RL   Mol. Cancer Ther. 4:399-412(2005).
//
RX   PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017;
RA   Kong, De-Xin
RA   Yamori, Takao
RT   "JFCR39, a panel of 39 human cancer cell lines, and its application in
RT   the discovery and development of anticancer drugs.";
RL   Bioorg. Med. Chem. 20:1947-1951(2012).
//
RX   PubMed=2170010;
RA   Sugimoto, Yoshikazu
RA   Tsukahara, Satomi
RA   Oh-hara, Tomoko
RA   Isoe, Toshiyuki
RA   Tsuruo, Takashi
RT   "Decreased expression of DNA topoisomerase I in camptothecin-resistant
RT   tumor cell lines as determined by a monoclonal antibody.";
RL   Cancer Res. 50:6925-6930(1990).
//