ID   HT-29 HD6
AC   CVCL_H254
SY   HD6
DR   cancercelllines; CVCL_H254
DR   Wikidata; Q54882123
RX   PubMed=2288877;
CC   Population: Caucasian.
CC   Characteristics: Clone of HT-29 established after treatment with hexamethylene bisacetamide (HMBA).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 21
//
RX   PubMed=2288877;
RA   Hafez M.M., Infante D., Winawer S., Friedman E.;
RT   "Transforming growth factor beta 1 acts as an autocrine-negative
RT   growth regulator in colon enterocytic differentiation but not in
RT   goblet cell maturation.";
RL   Cell Growth Differ. 1:617-626(1990).
//