ID   ARAC-8C
AC   CVCL_GZ09
SY   CCRF-CEM-AraC-8C; CEM/ARAC-8C; AraC-8C; Ara-C/8C
DR   cancercelllines; CVCL_GZ09
DR   TOKU-E; 4127
DR   Wikidata; Q54750420
RX   PubMed=2842332;
RX   PubMed=18279955;
WW   Provider; ICOregon; 1626-A; https://web.archive.org/web/20230206214932/http://icoregon.technologypublisher.com/technology/18057
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_28680; Cytarabine (Arabinosylcytosine; Ara-C).
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 10-04-25; Version: 18
//
RX   PubMed=18279955; DOI=10.1016/j.leukres.2007.12.015; PMCID=PMC2494856;
RA   Huang, Min
RA   Wang, Yan-Hong
RA   Gu, Jing-Jin
RA   Yang, Jing
RA   Noel, Karen
RA   Mitchell, Beverly S.
RA   Schramm, Vern L.
RA   Graves, Lewis M.
RT   "Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells
RT   to immucillin-H.";
RL   Leuk. Res. 32:1268-1278(2008).
//
RX   PubMed=2842332; DOI=10.1016/S0021-9258(18)37768-8;
RA   Ullman, Buddy
RA   Coons, Terry
RA   Rockwell, Susan
RA   McCartan, Kathleen
RT   "Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured
RT   human T lymphoblasts.";
RL   J. Biol. Chem. 263:12391-12396(1988).
//