ID   CH7C17
AC   CVCL_GX97
SY   CH7-C17
DR   cancercelllines; CVCL_GX97
DR   TOKU-E; 4175
DR   Wikidata; Q54811640
RX   PubMed=1588277;
RX   PubMed=7614994;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 12155; TRB (from HA1.7).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1316 ! J.RT3-T3.5
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 9
//
RX   PubMed=1588277; DOI=10.1084/jem.175.6.1493;
RA   Hewitt C.R.A., Lamb J.R., Hayball J., Hill M., Owen M.J., O'Hehir R.E.;
RT   "Major histocompatibility complex independent clonal T cell anergy by
RT   direct interaction of Staphylococcus aureus enterotoxin B with the T
RT   cell antigen receptor.";
RL   J. Exp. Med. 175:1493-1499(1992).
//
RX   PubMed=7614994; DOI=10.1002/eji.1830250627;
RA   Wedderburn L.R., Searle S.J.M., Rees A.R., Lamb J.R., Owen M.J.;
RT   "Mapping T cell recognition: the identification of a T cell receptor
RT   residue critical to the specific interaction with an influenza
RT   hemagglutinin peptide.";
RL   Eur. J. Immunol. 25:1654-1662(1995).
//