ID   HCC60
AC   CVCL_G002
SY   HCC0060; Hamon Cancer Center 60
DR   EFO; EFO_0006418
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03473068
DR   cancercelllines; CVCL_G002
DR   Cosmic; 1113279
DR   EGA; EGAS00001000610
DR   PharmacoDB; HCC60_507_2019
DR   Wikidata; Q54881769
RX   PubMed=12429618;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a NCI-H23 derivative (PubMed=25877200). Originally thought to originate from a 26 year old female patient with an ovarian cystadenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00533.
CC   Population: African American.
CC   HLA typing: A*80:01,80:01; B*50:01,50:01; C*06:02,06:02; DQB1*06:13,06:13; DRB1*13:01,03:17 (PubMed=26589293).
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:795; ATM; Simple; p.Gln1919Pro (c.5756A>C); ClinVar=VCV000580726; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Trp332Ter (c.996G>A); ClinVar=VCV000376339; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met246Ile (c.738G>C); ClinVar=VCV001758655; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 11
ST   D18S51: 14
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 9,10
ST   D8S1179: 15
ST   FGA: 24
ST   Penta D: 8
ST   Penta E: 7,17
ST   TH01: 6
ST   TPOX: 8,9
ST   vWA: 16,17
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1547 ! NCI-H23
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 27
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=12429618;
RA   Rathi, Asha
RA   Virmani, Arvind K.
RA   Schorge, John O.
RA   Elias, Keren J.
RA   Maruyama, Riichiroh
RA   Minna, John D.
RA   Mok, Samuel C.
RA   Girard, Luc
RA   Fishman, David A.
RA   Gazdar, Adi F.
RT   "Methylation profiles of sporadic ovarian tumors and nonmalignant
RT   ovaries from high-risk women.";
RL   Clin. Cancer Res. 8:3324-3331(2002).
//