ID   COS-1/B2T.cl.17
AC   CVCL_FA30
DR   Wikidata; Q54814312
RX   PubMed=24709903;
CC   Group: Non-human primate cell line.
CC   Characteristics: Transfected with a TNFRSF13C-TNFRSF1A (BAFFR-TNFR1) hybrid receptor containing the extracellular BAFF-binding portion of the TNFRSF13C and the intracellular signaling portion of TNFRSF1A.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:17755; TNFRSF13C (Note=AA 1-78).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11916; TNFRSF1A (Note=AA 204-443).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSV6-1).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9534; ! Chlorocebus aethiops (Green monkey)
HI   CVCL_0223 ! COS-1
SX   Male
AG   Adult
CA   Transformed cell line
DT   Created: 26-09-16; Last updated: 19-12-24; Version: 11
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RX   PubMed=24709903; DOI=10.3390/cells3010079; PMCID=PMC3980743;
RA   Hu J., Yu Y.-B., Han H., Civoli F., Zhuang Y., Thomas J., Swanson S.,
RA   Jing S.-Q., Gupta S.;
RT   "Development of a novel BAFF responsive cell line suitable for
RT   detecting bioactive BAFF and neutralizing antibodies against
RT   BAFF-pathway inhibiting therapeutics.";
RL   Cells 3:79-91(2014).
//