ID   EDITGENE BRCA1 Overexpression HCC1937 Stable Cell Line
AC   CVCL_F6FU
SY   BRCA1 Overexpression HCC1937 Stable Cell Line
DR   EDITGENE; EDC01719
CC   Population: Caucasian.
CC   Characteristics: Growth mode Adherent.
CC   Sequence variation: Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Gln1756Profs*74 (c.5266dupC) (5382insC); ClinVar=VCV000017677; Zygosity=Homozygous; Note=The lymphoblastoid cell line HCC1937 BL (Cellosaurus=CVCL_3281) is heterozygous for the same mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Thr738_Arg775del38 (c.2212_2325del114); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11876; TMPRSS2; Simple; p.Gly8Val (c.23G>T) (c.-57+99G>T); ClinVar=VCV001273671; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11876; TMPRSS2; Simple; p.Val197Met (c.589G>A) (p.Val160Met, c.478G>A); ClinVar=VCV001257425; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
DI   NCIt; C4017; Breast ductal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0290 ! HCC1937
SX   Female
AG   24Y
CA   Cancer cell line
DT   Created: 25-06-26; Last updated: 25-06-26; Version: 1
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