ID   NCR-EW3
AC   CVCL_F679
DR   Cosmic; 1087463
DR   Wikidata; Q54908249
RX   PubMed=1764362;
RX   PubMed=9738976;
RX   PubMed=9858836;
RX   PubMed=12054564;
CC   Population: Japanese.
CC   Doubling time: 55.4 hours (PubMed=1764362).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3493; ETV4 + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ETV4, EWSR1-E1AF (PubMed=9858836; PubMed=9738976).
CC   Derived from site: In situ; Chest wall; UBERON=UBERON_0016435.
DI   NCIt; C7135; Extraskeletal Ewing sarcoma
DI   ORDO; Orphanet_370334; Extraskeletal Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   10Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 18
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RX   PubMed=1764362; DOI=10.1038/bjc.1991.458; PMCID=PMC1977836;
RA   Hara S., Adachi Y., Kaneko Y., Fujimoto J.-i., Hata J.-i.;
RT   "Evidence for heterogeneous groups of neuronal differentiation of
RT   Ewing's sarcoma.";
RL   Br. J. Cancer 64:1025-1030(1991).
//
RX   PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x; PMCID=PMC5921883;
RA   Urano F., Umezawa A., Yabe H., Hong W., Yoshida K., Fujinaga K.,
RA   Hata J.-i.;
RT   "Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF,
RT   available for diagnosis.";
RL   Jpn. J. Cancer Res. 89:703-711(1998).
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RX   PubMed=9858836; DOI=10.1159/000015119;
RA   Ishida S., Yoshida K., Kaneko Y., Tanaka Y., Sasaki Y., Urano F.,
RA   Umezawa A., Hata J.-i., Fujinaga K.;
RT   "The genomic breakpoint and chimeric transcripts in the
RT   EWSR1-ETV4/E1AF gene fusion in Ewing sarcoma.";
RL   Cytogenet. Cell Genet. 82:278-283(1998).
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RX   PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8;
RA   Yabe H., Fukuma M., Urano F., Yoshida K., Kato S., Toyama Y., Hata J.-i.,
RA   Umezawa A.;
RT   "Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing
RT   sarcoma may be due to loss of accessibility of the MMP regulatory
RT   element to the specific fusion protein in vivo.";
RL   Biochem. Biophys. Res. Commun. 293:61-71(2002).
//