ID   EDITGENE A375-Cas9
AC   CVCL_F5NV
SY   A375-Cas9
DR   EDITGENE; EDC01052
CC   Population: Caucasian.
CC   Characteristics: Growth mode Adherent.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
CC   Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
ST   Source(s): EDITGENE=EDC01052
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D12S391: 18,21
ST   D13S317: 11,14
ST   D16S539: 9
ST   D18S51: 12,17
ST   D19S433: 13,14.2
ST   D21S11: 29,30
ST   D2S1338: 16,24
ST   D2S441: 11
ST   D3S1358: 15,17
ST   D5S818: 12
ST   D6S1043: 11,14
ST   D7S820: 9
ST   D8S1179: 11,14
ST   FGA: 23
ST   Penta D: 9,15
ST   Penta E: 10,12
ST   TH01: 8
ST   TPOX: 8,10
ST   vWA: 16,17
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 25-06-26; Last updated: 25-06-26; Version: 1
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