ID   EPC2-hTERT
AC   CVCL_F4C2
RX   PubMed=12939398;
CC   Characteristics: p16INK4a (CDKN2A) is wild-type and functionally active (UV-inducible; binds CDK4/6). p53 (TP53) is wild-type and functionally active (PubMed=12939398).
CC   Characteristics: Expresses cytokeratins 5 and 14 (PubMed=12939398).
CC   Characteristics: Displays basal cell hyperplasia but not malignant transformation in organotypic culture (PubMed=12939398).
CC   Karyotypic information: Normal diploid karyotype (PubMed=12939398).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Epithelium of esophagus; UBERON=UBERON_0001976.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_F4C3 ! EPC2
SX   Sex unspecified
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 25-06-26; Last updated: 25-06-26; Version: 1
//
RX   PubMed=12939398;
RA   Harada, Hideki
RA   Nakagawa, Hiroshi
RA   Oyama, Kenji
RA   Takaoka, Munenori
RA   Andl, Claudia D.
RA   Jacobmeier, Birgit
RA   von Werder, Alexander
RA   Enders, Gregory H.
RA   Opitz, Oliver G.
RA   Rustgi, Anil K.
RT   "Telomerase induces immortalization of human esophageal keratinocytes
RT   without p16INK4a inactivation.";
RL   Mol. Cancer Res. 1:729-738(2003).
//