ID   HeLa TRIP13 KO: auxin-inducible degron (AID)-TRIP13-Tet-Off.
AC   CVCL_F4BW
SY   TRIP13 KO:AID; Clone 9; TRIP13KO AID-TRIP13
RX   PubMed=29425500;
CC   Population: African American.
CC   Characteristics: Expresses AID-TRIP13 under the control of a Tet-Off promoter in TRIP13 knockout background. Expression of AID-TRIP13 is suppress by doxycycline and indole-3-acetic acid (IAA).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:12307; TRIP13.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:12307; TRIP13 (Note=With a N-ter AID tag).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P93830; Arabidopsis thaliana IAA17 (Note=acts as an auxin-inducible degron (AID)).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; Q570C0; Arabidopsis thaliana TIR1 (Note=With a Myc tag).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Arg360del).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2523 ! HtTA-1
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 25-06-26; Last updated: 25-06-26; Version: 1
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RX   PubMed=29425500; DOI=10.1016/j.celrep.2018.01.027;
RA   Ma, Hoi Tang
RA   Poon, Randy Y.C.
RT   "TRIP13 functions in the establishment of the spindle assembly
RT   checkpoint by replenishing O-MAD2.";
RL   Cell Rep. 22:1439-1450(2018).
//