ID   XP2BE
AC   CVCL_F491
SY   Xeroderma Pigmentosum 2 BEthesda; Ja Ar; GM00677; GM-677; GM 677; GM677; GM0677
DR   CLO; CLO_0028918
DR   ATCC; CRL-1166
DR   Coriell; GM00677
DR   JCRB; KURB1055
DR   Wikidata; Q54836386
RX   CelloPub=CLPUB00447;
RX   DOI=10.5962/bhl.title.4090;
RX   PubMed=273925;
RX   PubMed=4811796;
RX   PubMed=6492896;
RX   PubMed=6947227;
RX   PubMed=7163956;
RX   PubMed=7264357;
CC   Population: Caucasian.
CC   Senescence: Senesces at 22 PDL (PubMed=6492896).
CC   Sequence variation: Mutation; HGNC; 12816; XPC; Simple; p.Val696_Val697insVal (c.2092_2093insGTG); Zygosity=Homozygous (from familial inference of XP8BE; XP9BE).
CC   Discontinued: ATCC; CRL-1166; true.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C114770; Xeroderma pigmentosum, complementation group C
DI   ORDO; Orphanet_910; Xeroderma pigmentosum
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   25Y
CA   Finite cell line
DT   Created: 11-02-13; Last updated: 02-05-24; Version: 21
//
RX   CelloPub=CLPUB00447;
RA   Mulivor R.A., Suchy S.F.;
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992).
//
RX   DOI=10.5962/bhl.title.4090;
RA   Coriell L.L., Greene A.E.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 4th edition. October 1977.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-171; National Institutes of Health; Bethesda (1977).
//
RX   PubMed=273925; DOI=10.1073/pnas.75.4.1984;
RA   Andrews A.D., Barrett S.F., Robbins J.H.;
RT   "Xeroderma pigmentosum neurological abnormalities correlate with
RT   colony-forming ability after ultraviolet radiation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:1984-1988(1978).
//
RX   PubMed=4811796; DOI=10.7326/0003-4819-80-2-221;
RA   Robbins J.H., Kraemer K.H., Lutzner M.A., Festoff B.W., Coon H.G.;
RT   "Xeroderma pigmentosum. An inherited disease with sun sensitivity,
RT   multiple cutaneous neoplasms, and abnormal DNA repair.";
RL   Ann. Intern. Med. 80:221-248(1974).
//
RX   PubMed=6492896; DOI=10.1016/0047-6374(84)90044-7;
RA   Cleaver J.E.;
RT   "DNA repair deficiencies and cellular senescence are unrelated in
RT   xeroderma pigmentosum cell lines.";
RL   Mech. Ageing Dev. 27:189-196(1984).
//
RX   PubMed=6947227; DOI=10.1073/pnas.78.10.6236;
RA   Miskin R., Ben-Ishai R.;
RT   "Induction of plasminogen activator by UV light in normal and
RT   xeroderma pigmentosum fibroblasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:6236-6240(1981).
//
RX   PubMed=7163956; DOI=10.1007/BF01543020;
RA   Cleaver J.E.;
RT   "Rapid complementation method for classifying excision
RT   repair-defective xeroderma pigmentosum cell strains.";
RL   Somatic Cell Genet. 8:801-810(1982).
//
RX   PubMed=7264357; DOI=10.1111/1523-1747.ep12482447;
RA   Fujiwara Y., Ichihashi M., Kano Y., Goto K., Shimizu K.;
RT   "A new human photosensitive subject with a defect in the recovery of
RT   DNA synthesis after ultraviolet-light irradiation.";
RL   J. Invest. Dermatol. 77:256-263(1981).
//