ID   mCherry-NCOA4 LRRK2 G2019S RAW 264.7
AC   CVCL_F2A3
RX   DOI=10.1101/2025.08.25.672135;
CC   Characteristics: Transduced with a lentiviral pBABE-puro-mCHerrry-NCOA4 construct.
CC   Sequence variation: Mutation; MGI; MGI:1913975; Lrrk2; Simple_edited; p.Gly2019Ser (c.6055G>A); Zygosity=Homozygous; (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7671; NCOA4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C21604; Mouse leukemia
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_F1ZX ! LRRK2 G2019S RAW 264.7
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 31-03-26; Last updated: 31-03-26; Version: 1
//
RX   DOI=10.1101/2025.08.25.672135;
RA   Goldman, Andres
RA   Nguyen, Mai
RA   Lanoix, Joel
RA   Fahmy, Ahmed
RA   Zhong Xu, Yong
RA   Schurr, Erwin
RA   Thibault, Pierre
RA   Desjardins, Michel
RA   McBride, Heidi M.
RT   "LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload.";
RL   bioRxiv 2025:08.25.672135-08.25.672135(2025).
//