ID   LRRK2-ARM-KO RAW 264.7
AC   CVCL_F1ZZ
SY   LRRK2ARM-KO macrophages
RX   DOI=10.1101/2025.08.25.672135;
CC   Knockout cell: Method=CRISPR/Cas9; MGI; MGI:1913975; Lrrk2.
CC   Sequence variation: Mutation; MGI; MGI:1913975; Lrrk2; Unexplicit; Ex19_51del ; Zygosity=Homozygous; (from parent cell line).
CC   Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C21604; Mouse leukemia
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_F1ZY ! LRRK2-ARM RAW 264.7
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 31-03-26; Last updated: 31-03-26; Version: 1
//
RX   DOI=10.1101/2025.08.25.672135;
RA   Goldman, Andres
RA   Nguyen, Mai
RA   Lanoix, Joel
RA   Fahmy, Ahmed
RA   Zhong Xu, Yong
RA   Schurr, Erwin
RA   Thibault, Pierre
RA   Desjardins, Michel
RA   McBride, Heidi M.
RT   "LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload.";
RL   bioRxiv 2025:08.25.672135-08.25.672135(2025).
//