ID   LRRK2 G2019S RAW 264.7
AC   CVCL_F1ZX
SY   LRRK2G2019S macrophages
RX   DOI=10.1101/2025.08.25.672135;
CC   Sequence variation: Mutation; MGI; MGI:1913975; Lrrk2; Simple_edited; p.Gly2019Ser (c.6055G>A); Zygosity=Homozygous; Note=By CRISPR/Cas9 (DOI=10.1101/2025.08.25.672135).
CC   Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C21604; Mouse leukemia
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_0493 ! RAW 264.7
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 31-03-26; Last updated: 31-03-26; Version: 1
CH   CVCL_F2A1 ! mCherry-FTL LRRK2 G2019S RAW 264.7
CH   CVCL_F2A3 ! mCherry-NCOA4 LRRK2 G2019S RAW 264.7
CH   CVCL_F2A5 ! TMEM192-HA LRRK2 G2019S RAW 264.7
//
RX   DOI=10.1101/2025.08.25.672135;
RA   Goldman, Andres
RA   Nguyen, Mai
RA   Lanoix, Joel
RA   Fahmy, Ahmed
RA   Zhong Xu, Yong
RA   Schurr, Erwin
RA   Thibault, Pierre
RA   Desjardins, Michel
RA   McBride, Heidi M.
RT   "LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload.";
RL   bioRxiv 2025:08.25.672135-08.25.672135(2025).
//