ID   RAW 264.7 Lrrk2 KO + HALO-human LRRK2(3xRabmut)
AC   CVCL_F1Z4
SY   RAW 264.7 LRRK2 KO+Halo-human LRRK2(Rab binding mutant)
RX   DOI=10.1101/2025.11.19.689251;
CC   Knockout cell: Method=ZFN; MGI; MGI:1913975; Lrrk2.
CC   Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:18618; LRRK2 (Note=With p.Lys17Ala, p.Lys18Ala, p.Glu240Arg and p.Lys439Glu).
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P0A3G2; Rhodococcus rhodochrous dhaA (Note=Mutated = HaloTag).
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Macrophage; CL=CL_0000235.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C21604; Mouse leukemia
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_UL72 ! RAW 264.7 LRRK2 KO
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
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RX   DOI=10.1101/2025.11.19.689251;
RA   Clegg, Devin
RA   Bentley-DeSousa, Amanda
RA   Roczniak-Ferguson, Agnes
RA   Ferguson, Shawn M.
RT   "LRRK2 integrates Rab and GABARAP interactions to sense and respond to
RT   distinct lysosomal stresses.";
RL   bioRxiv 2025:11.19.689251-11.19.689251(2025).
//