ID   CCRF-CEM C7 4R4
AC   CVCL_F1W8
SY   CEM-4R4; 4R4
RX   PubMed=1972702;
RX   PubMed=6965106;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_41879; Dexamethasone.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6825 ! CCRF-CEM C7
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
//
RX   PubMed=6965106; DOI=10.1128/mcb.1.6.512-521.1981; PMCID=PMC369694;
RA   Harmon, Jeffrey M.
RA   Thompson, E. Brad
RT   "Isolation and characterization of dexamethasone-resistant mutants
RT   from human lymphoid cell line CEM-C7.";
RL   Mol. Cell. Biol. 1:512-521(1981).
//
RX   PubMed=1972702; DOI=10.1007/BF02624204;
RA   Chilton, David G.
RA   Johnson, Betty H.
RA   Danel-Moore, Laurence
RA   Kawa, Simon
RA   Thompson, E. Brad
RT   "Increased glucocorticoid responsiveness of CD4+ T-cell clonal lines
RT   grown in serum-free media.";
RL   In Vitro Cell. Dev. Biol. 26:561-570(1990).
//