ID   HyCyte 143B KO-hIBSP
AC   CVCL_F1LH
SY   hIBSP knockout 143B
DR   Hysigen; CGKO-M3273
CC   Population: Caucasian.
CC   Doubling time: 36-48 hours (Hysigen=CGKO-M3273).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:5341; IBSP.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2270 ! 143B
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
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