ID   DT40-TDP2(-/-/-) hTDP2 D262A
AC   CVCL_F1KR
SY   TDP2-/-/- hTDP2D262A
RX   PubMed=21030584;
CC   Group: Bird cell line.
CC   Knockout cell: Method=Targeted integration; CGNC; 10219; TDP2.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:17768; TDP2 (Note=With p.Asp262Ala).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
CC   Cell type: B-cell; CL=CL_0000236.
CC   Breed/subspecies: Hy-Line SC.
DI   NCIt; C134556; Chicken bursal lymphoma
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
HI   CVCL_F1BX ! DT40-TDP2(-/-/-) clone 8
SX   Female
AG   1D
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
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RX   PubMed=21030584; DOI=10.1074/jbc.M110.181016; PMCID=PMC3012998;
RA   Zeng, Zhi-Hong
RA   Cortes-Ledesma, Felipe
RA   El-Khamisy, Sherif Faruk
RA   Caldecott, Keith W.
RT   "TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in
RT   vertebrate cells and is critical for cellular resistance to
RT   topoisomerase II-induced DNA damage.";
RL   J. Biol. Chem. 286:403-409(2011).
//