ID   THP-1 K5 P/A
AC   CVCL_F1K5
RX   PubMed=21490960;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P90489; Human herpesvirus 8 type P (isolate GK18) E3 ubiquitin-protein ligase MIR2 (K5) (Note=With p.Pro167Ala, p.Arg169Ala, p.Pro171Ala and p.Pro174Ala).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
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RX   PubMed=21490960; DOI=10.1371/journal.ppat.1001331; PMCID=PMC3072377;
RA   Karki, Roshan
RA   Lang, Sabine Martha
RA   Means, Robert E.
RT   "The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism
RT   and proliferation through receptor tyrosine kinase modulation.";
RL   PLoS Pathog. 7:e1001331.1-e1001331.15(2011).
//