ID   MCF-7/HRG-T8
AC   CVCL_F1C7
SY   MCF-7/T8
RX   PubMed=8764133;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7997; NRG1 (Note=Isoform beta-2).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
//
RX   PubMed=8764133;
RA   Tang, Careen K.
RA   Perez, Cynthia
RA   Grunt, Thomas W.
RA   Waibel, Caroline
RA   Cho, Cheryl
RA   Lupu, Ruth
RT   "Involvement of heregulin-beta2 in the acquisition of the
RT   hormone-independent phenotype of breast cancer cells.";
RL   Cancer Res. 56:3350-3358(1996).
//