ID   DT40-TDP2(-/-/-) clone 8
AC   CVCL_F1BX
SY   TDP2-/-/- clone 8
RX   PubMed=21030584;
CC   Group: Bird cell line.
CC   Knockout cell: Method=Targeted integration; CGNC; 10219; TDP2.
CC   Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
CC   Cell type: B-cell; CL=CL_0000236.
CC   Breed/subspecies: Hy-Line SC.
DI   NCIt; C134556; Chicken bursal lymphoma
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
HI   CVCL_0249 ! DT40
SX   Female
AG   1D
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
CH   CVCL_F1KQ ! DT40-TDP2(-/-/-) hTDP2
CH   CVCL_F1KR ! DT40-TDP2(-/-/-) hTDP2 D262A
//
RX   PubMed=21030584; DOI=10.1074/jbc.M110.181016; PMCID=PMC3012998;
RA   Zeng, Zhi-Hong
RA   Cortes-Ledesma, Felipe
RA   El-Khamisy, Sherif Faruk
RA   Caldecott, Keith W.
RT   "TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in
RT   vertebrate cells and is critical for cellular resistance to
RT   topoisomerase II-induced DNA damage.";
RL   J. Biol. Chem. 286:403-409(2011).
//