ID   HepG2/STAT3
AC   CVCL_F1AI
RX   PubMed=37315652;
CC   Population: Caucasian.
CC   Characteristics: Used to monitor the activation of the STAT3 signaling pathway. Sensitive to interleukin-6 (IL6) (PubMed=37315652).
CC   Characteristics: Transfected with the pGL4.47[luc2P/SIE/Hygro] plasmid that contains a synthetic firefly luciferase (luc2P) gene under the control of five copies of the SIS-inducible element (SIE) (PubMed=37315652).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression and a PEST sequence = Luc2P).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
//
RX   PubMed=37315652; DOI=10.1016/j.jep.2023.116700;
RA   Ni, Lian-Li
RA   Che, Yi-Hao
RA   Sun, Hong-Mei
RA   Wang, Bo
RA   Wang, Mei-Yu
RA   Yang, Zi-Zhong
RA   Liu, Heng
RA   Xiao, Huai
RA   Yang, Da-Song
RA   Zhu, Hui-Lin
RA   Yang, Zhi-Bin
RT   "The therapeutic effect of wasp venom (Vespa magnifica, Smith) and its
RT   effective part on rheumatoid arthritis fibroblast-like synoviocytes
RT   through modulating inflammation, redox homeostasis and ferroptosis.";
RL   J. Ethnopharmacol. 317:116700.1-116700.15(2023).
//