ID   HEK293 TDP-43 A315T
AC   CVCL_F0RA
RX   PubMed=31100073;
CC   Characteristics: Using a pcDNA4/TO/myc-His based construct TARDBP/TDP-43 was transfected and its expression is regulated by doxycycline (PubMed=31100073).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11571; TARDBP (Note=With p.Ala315Thr and a C-terminal mycHis6 tag).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D585 ! T-REx-293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
//
RX   PubMed=31100073; DOI=10.1371/journal.pgen.1007947; PMCID=PMC6524796;
RA   Wang, Peng
RA   Deng, Jian-Wen
RA   Dong, Jie
RA   Liu, Jiang-Hong
RA   Bigio, Eileen H.
RA   Mesulam, Marek Marsel
RA   Wang, Tao
RA   Sun, Lei
RA   Wang, Li
RA   Lee, Alan Yueh-Luen
RA   McGee, Warren A.
RA   Chen, Xiao-Ping
RA   Fushimi, Kazuo
RA   Zhu, Li
RA   Wu, Jane Ying
RT   "TDP-43 induces mitochondrial damage and activates the mitochondrial
RT   unfolded protein response.";
RL   PLoS Genet. 15:e1007947.1-e1007947.32(2019).
//