ID   AGS-4
AC   CVCL_F0QR
RX   PubMed=6678861;
RX   PubMed=6831414;
CC   Population: Caucasian.
CC   Doubling time: 28 hours (PubMed=6831414).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly34Glu (c.101G>A); ClinVar=VCV000017584; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu453Lys (c.1357G>A); ClinVar=VCV000376470; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Ala (c.1634A>C); ClinVar=VCV000013659; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:667; RHOA; Simple; p.Glu64del (c.192_194del); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Stomach; UBERON=UBERON_0000945.
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0139 ! AGS
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 27-11-25; Last updated: 27-11-25; Version: 1
//
RX   PubMed=6678861; DOI=10.1007/BF00172070;
RA   Barranco, Sam Christopher
RA   Townsend, Courtney M. Jr.
RA   Quraishi, M.A.
RA   Burger, N.L.
RA   Nevill, H.C.
RA   Howell, K.H.
RA   Boerwinkle, William Robert
RT   "Heterogeneous responses of an in vitro model of human stomach cancer
RT   to anticancer drugs.";
RL   Invest. New Drugs 1:117-127(1983).
//
RX   PubMed=6831414;
RA   Barranco, Sam Christopher
RA   Townsend, Courtney M. Jr.
RA   Casartelli, Cacilda
RA   Macik, Barbara Gail
RA   Burger, N.L.
RA   Boerwinkle, William Robert
RA   Gourley, William Kneff
RT   "Establishment and characterization of an in vitro model system for
RT   human adenocarcinoma of the stomach.";
RL   Cancer Res. 43:1703-1709(1983).
//