ID   HT29-MTX resistant (10 microMolar)
AC   CVCL_F0KN
SY   HT29-MTX resistant (10-5M)
DR   ECACC; 15121711
RX   PubMed=2205381;
CC   Population: Caucasian.
CC   Characteristics: Resistant to 10 muM of methotrexate (PubMed=2205381).
CC   Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ECACC=15121711
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 13,20.2
ST   D21S11: 29
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 9.3
ST   D8S1179: 10
ST   FGA: 20,22
ST   Penta D: 11
ST   Penta E: 14,16
ST   TH01: 6,9
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0320 ! HT-29
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 14-08-25; Last updated: 14-08-25; Version: 1
//
RX   PubMed=2205381;
RA   Lesuffleur, Thecla
RA   Barbat, Alain
RA   Dussaulx, Elisabeth
RA   Zweibaum, Alain
RT   "Growth adaptation to methotrexate of HT-29 human colon carcinoma
RT   cells is associated with their ability to differentiate into columnar
RT   absorptive and mucus-secreting cells.";
RL   Cancer Res. 50:6334-6343(1990).
//