ID   CCRF-CEM C7H2
AC   CVCL_EP75
SY   CCRF-CEM-C7H2; CEM-C7H2; CEM-C7.H2; CEM-C7-H2; CEMC7H2; C7H2
DR   cancercelllines; CVCL_EP75
DR   GEO; GSM286229
DR   GEO; GSM286230
DR   GEO; GSM286231
DR   GEO; GSM286232
DR   GEO; GSM286233
DR   GEO; GSM286234
DR   GEO; GSM286235
DR   GEO; GSM286236
DR   GEO; GSM286237
DR   GEO; GSM286238
DR   GEO; GSM286239
DR   GEO; GSM286240
DR   Wikidata; Q54809019
RX   PubMed=7812967;
RX   PubMed=8895760;
RX   PubMed=10467407;
RX   PubMed=15637111;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): PubMed=15637111
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,12
ST   D16S539: 10,13
ST   D18S51: 13,17
ST   D21S11: 30,33.2
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 9,12
ST   D8S1179: 13
ST   FGA: 23
ST   Penta D: 11
ST   Penta E: 5,14
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 17,19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6825 ! CCRF-CEM C7
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 05-10-23; Version: 17
//
RX   PubMed=7812967;
RA   Strasser-Wozak E.M.C., Hattmannstorfer R., Hala M., Hartmann B.L.,
RA   Fiegl M., Geley S., Kofler R.;
RT   "Splice site mutation in the glucocorticoid receptor gene causes
RT   resistance to glucocorticoid-induced apoptosis in a human acute
RT   leukemic cell line.";
RL   Cancer Res. 55:348-353(1995).
//
RX   PubMed=8895760;
RA   Geley S., Hartmann B.L., Hala M., Strasser-Wozak E.M.C., Kapelari K.,
RA   Kofler R.;
RT   "Resistance to glucocorticoid-induced apoptosis in human T-cell acute
RT   lymphoblastic leukemia CEM-C1 cells is due to insufficient
RT   glucocorticoid receptor expression.";
RL   Cancer Res. 56:5033-5038(1996).
//
RX   PubMed=10467407; DOI=10.1038/sj.onc.1202820;
RA   Loffler M., Ausserlechner M.J., Tonko M., Hartmann B.L., Bernhard D.,
RA   Geley S., Helmberg A., Kofler R.;
RT   "c-Myc does not prevent glucocorticoid-induced apoptosis of human
RT   leukemic lymphoblasts.";
RL   Oncogene 18:4626-4631(1999).
//
RX   PubMed=15637111; DOI=10.1096/fj.04-3062fje;
RA   Parson W., Kirchebner R., Muhlmann R., Renner K., Kofler A.,
RA   Schmidt S., Kofler R.;
RT   "Cancer cell line identification by short tandem repeat profiling:
RT   power and limitations.";
RL   FASEB J. 19:434-436(2005).
//